Vanderbilt School of Medicine Basic Sciences on LinkedIn: David Cortez wins Protein Society award for contributions to basic protein… (2024)

This book reviews recent progress in understanding of the signaling and biochemistry of GM3 ganglioside in eukaryotic cells. GM3 is the simplest of the gangliosides and the precursor of other gangliosides. It is expressed in the outer leaflet of plasma cell membranes and has roles in the recognition, interaction, binding, adhesion, and motility of cells. In addition, GM3 has been documented to have functional roles in cell migration, proliferation, senescence, and apoptosis. The full range of topics of interest are addressed in the book. The early chapters discuss the synthesis of GM3, its molecular localization in cells, and its basic function as an interacting molecule. The ways in which GM3 exerts its effects via various growth factor receptors are fully explored. Current knowledge of the part played by GM3 in health and disease is discussed in depth. For example, its roles in preventing inflammation, inhibiting tumor angiogenesis and tumor growth, and suppressing arthritis are highlighted, and attention drawn to the significance of GM3 as a driver of impaired wound healing in diabetics. The book will be of interest to all who want a comprehensive update on research in this field.Molecular and Cellular Glycobiology Lab Department of Biological Sciences, College of Science, Sungkyunkwan University, Suwon, Korea (Republic of)Cheorl-Ho Kim#Gangliosde#GM3#Sialic acid#sugar code#Anti-Tumor#EGFR-GM3 interaction#VEGFR#HGFR#FGFR#PDGFR-GM3#Neuraminidase#gene expression

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“Odense is to proteomics what Nashville is to country music.”— Stephen G. Oliver, University of Manchester.This week, six of our protein scientists, along with CEO Thomas Kofoed and graduate student Martine Taagholt, attended #DAPSOC, the Danish Proteomics Society’s yearly symposium hosted in Odense by Ole Nørregaard Jensen and the Faculty of Science, University of Southern Denmark.Why in Odense specifically? Because the per capita concentration of proteomics experts in Odense is the highest in the world! 🤯#Proteomics is the study of the expressed protein complement of a genome and is one of the most significant methodologies for comprehending gene functions in both human and bacterial cells. 🦠🧫Studying the complex dynamics of protein interactions is crucial for disease diagnostics and identifying target molecules for drug development. The keynote speakers at the DAPSOC symposium covered, among other things, topics related to cancer treatment, cardiovascular disease and aortic aneurism detection, diabetes, and neonatal care.From Alphalyse, Thomas Kofoed, Christina Erika Hagensen, Sigurd Frederiksen Maša Babović, Tine Nielsen, Victor Chrone, Marcella N Melo-Braga, and Martine Taagholt (right to left) attended the symposium to network with fellow protein scientists, learn about leading research in the field, and exchange information about new technology with representatives from our business partners.

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#Mitochondrial sirtuins have been the subject of significant attention over the past two decades, with studies indicating that they play a role in various age-related diseases. A new study published in Nature Portfolio Chemical Biology used #nontargeted metabolomics to screen for sirtuin-dependent metabolic changes, and identified a family of previously uncharacterized N-acylspermidines downstream of mitochondrial sirtuins.The discovery of this branch of conserved sirtuin-related biochemistry can facilitate inference of the in vivo function of mitochondrial sirtuins and contribute to a mechanistic understanding of their roles in cancer and other diseases. Read the paper here: https://lnkd.in/exrKwGDp

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I am excited to share with you one of our latest articles. Finally, my thesis project has been published! 🤩🥳We developed a method to optimize bacterial overexpression of the functionally active human amino acid transporter SNAT2 (SLC38A2). Since SNAT2 is involved in several biological processes, including cancer, this work can be a starting point for further studies. Special thanks to my supervisors. Cesare Indiveri Michele Gallucciohttps://rdcu.be/dztSbSpringer Nature Group #slctransporters #membraneprotein #SLC38A2 #SLC38 #Ecoli #molecularbiology #biochemistry #proteoliposomes #glutaminetransporter

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🔬 Exciting Research Alert! 🔬We're thrilled to share a groundbreaking study titled "Cell biology of protein–lipid conjugation" by Jun-ichi Sakamaki and Noboru Mizushima from the Department of Biochemistry and Molecular Biology, Graduate School of Medicine, The University of Tokyo.This research provides a comprehensive overview of protein-lipid conjugation, a critical process in cell biology that plays a significant role in the regulation of protein function and localization. The study delves into the intricacies of this process, highlighting its implications in various biological phenomena and diseases.At Amira Therapeutics, we're particularly interested in this research as it sheds light on the Hedgehog (Hh) pathway, a key area of our focus. Our lead candidate, AMI463, is a novel inhibitor of the Hh pathway coreceptor, CDO, and this research provides valuable insights that could further our understanding of its mechanism of action.We're always excited to see advancements in this field, and we're committed to leveraging these insights to drive our mission of developing innovative therapies for pediatric cancers.For those interested in the details of this study, you can access it here: https://lnkd.in/eNBU-dKw#AmiraTherapeutics #ResearchHighlight #CellBiology #ProteinLipidConjugation #HedgehogPathway #CancerResearch

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Excited to share the most recent work from our lab led by the brilliant biochemistry graduate student, Uche Medoh. In this work, we discover the long-sought enzyme that produces the lysosomal lipid known as bis(monoacylglycero)phosphate (BMP). Lysosomal function is crucial. In particular, the lysosome's ability to recycle lipids is key to human health. Lipid catabolism in the lysosome requires BMPs, and alterations in BMP levels are associated with neurodegenerative diseases. This discovery provides a framework to understand fundamental aspects of BMP biology and to test the therapeutic potential of activating BMP synthesis in neurodegeneration and other human conditions.The news:https://lnkd.in/gyXUhQjXThe original paper in Science Magazine:https://lnkd.in/g6tMnHN5

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Are you using engineered cell models, co-culture systems, organoids, or tumor slice cultures? Are you currently able to capture the full immune response? Find out how Nomic can help make this possible at the SITC conference in San Diego 🌆.📌Join us at Poster #61, where we present "Treatment-Specific Immune Phenotypes in PBMCs Revealed by nELISA High-Throughput Proteomics."Don't miss this opportunity to discover our high throughput protein profiling technology and its potential to reshape immuno-oncology research. See you at the conference!#Nomic #nELISA #SITC2023 #ImmunoOncology

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We are thrilled to announce our latest manuscript "An Inflection Point in High-Throughput Proteomics with Orbitrap Astral: Analysis of Biofluids, Cells, and Tissues."Here are the key highlights from our study:🔻 Efficient workflow - High-throughput workflows for automated sample preparation and rapid analysis of diverse biospecimens using the #Orbitrap #Astral MS platform.🔻 Comprehensive proteome coverage - Exceeding 10,000 protein IDs in cells and tissues within a 24-minute gradient.🔻 Biomarker identification - Significant number of FDA-approved protein biomarkers in plasma.🔻 Precision analysis - High-quality quantitative measurements with CVs performing exceptionally well at short gradients, enabling high-throughput analyses with impressive precision.Read more: https://lnkd.in/gH6iPKrb#Orbitrap #Astral #proteomics #massspectrometry #biomarkers #precisionmedicine #highthoughput

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Greetings everyone!I am writing this to share my review paper "Shaking Hands with Streptococcal Antibody-Degrading Enzymes for Clinical Use" is published in Applied Biochemistry and Microbiology journal. I extend a warm thanks to my co-authors Sanskar Srivastava and Ishika Gulati for their valuable contributions to the conceptualization of the paper, literature search and manuscript preparation. The paper talks about the potential use of bacterial weapons, IgG-degrading enzymes of Streptococcus pyogenes specifically, against our immune system in clinical settings for antibody-mediated conditions and the manufacture of antibody-based interventions. The paper would attract an audience interested in clinical and applied microbiology, immunology, and experimental medicine. Here's the DOI to the paper: https://lnkd.in/g8St6WEX

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The study of Cell Biology revolves around the structure and function of cells in both prokaryotic and eukaryotic domains. The course provides an insight into cell structures, cellular metabolism, cell signalling, cell cycle, and other aspects of cellular biochemistry at the molecular level. Cells form the fundamental unit of life and understanding cellular functions and behaviour can help to understand complex multicellular organisms and biological systems. The concepts discussed in this course help to create a strong background for understanding advanced concepts in cancer biology, genetics, microbiology, molecular biology, immunogenomics, and others.Learn more https://lnkd.in/exPDjJ6R

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